Membrane dynamics in Leishmania amazonensis and antileishmanial activities of β-carboline derivatives

 

 

 

 

Two β-carboline compounds, 8i and 6d, demonstrated in vitro antileishmanial exercise towards Leishmania (L.) amazonensis promastigotes just like that of miltefosine (MIL). Estimates of the membrane-water partition coefficient (OkM/W) and the compound concentrations within the membrane (cm50) and aqueous section (cw50) for half maximal inhibitory focus had been made. Whereas these biophysical parameters for 6d weren’t considerably completely different from these reported for MIL, 8i confirmed decrease affinity for the parasite membrane (decrease OkM/W) and a decrease focus of the compound within the membrane required to inhibit the expansion of the parasite (decrease cm50).

A 2-hour remedy of Leishmania promastigotes with the compounds 8i and 6d prompted membrane rigidity in a concentration-dependent method, as demonstrated by the electron paramagnetic resonance (EPR) method and spin label methodology. This elevated rigidity of the membrane was interpreted to be related to the incidence of cross-linking of oxidized cytoplasmic proteins to the parasite membrane skeleton. Importantly, the 2 β-carboline-oxazoline derivatives confirmed low hemolytic motion, each in experiments with remoted purple blood cells or with complete blood, denoting their nice Leishmania/erythrocyte selectivity index.

Utilizing electron microscopy, modifications within the membrane of each the amastigote and promastigote type of the parasite had been confirmed, and it was demonstrated that compounds 8i and 6d decreased the variety of amastigotes in contaminated murine macrophages. Moreover, 8i and 6d had been extra poisonous to the protozoa than to J774A.1 macrophages, with handled promastigotes exhibiting a lower in cell quantity, mitochondrial membrane potential depolarization, accumulation of lipid our bodies, elevated ROS manufacturing and modifications within the cell cycle. Serum samples had been collected from 250 canine and examined utilizing oblique enzyme-linked immunosorbent assay (ELISA) and oblique immunofluorescence antibody exams (IFATs). Information regarding canine, their surroundings, and their house owners’ data of leishmaniasis had been collected utilizing a questionnaire. To find out RFs for contact with the parasite, univariate statistical evaluation based mostly on chi-squared and Fisher’s actual exams, adopted by logistic regression, was used.

 

Canine visceral leishmaniasis in space with current Leishmania transmission: prevalence, prognosis, and molecular identification of the infecting species

Introduction: Canine visceral leishmaniasis (CVL) is an endemic illness in Brazil, and built-in management actions have been adopted by the Brazilian Ministry of Well being to manage its unfold. Nevertheless, the transmission profile is unknown in areas with current CVL instances, together with Itaúna, positioned within the Brazilian state of Minas Gerais, the place the current examine was carried out.
Strategies: A complete of two,302 canine from 12 neighborhoods had been serologically examined for canine VL utilizing the present diagnostic protocol adopted by the Brazilian Ministry of Well being. Check positivity fee (TPR) and CVL prevalence had been decided for every neighborhood. The presence of Leishmania was assessed in 60 seropositive canine which had been really helpful for euthanasia. Twenty-two of them (37%) had been asymptomatic, and 38 (63%) had been symptomatic for CVL. Parasitological (myeloculture and smear/imprint) and molecular (PCR) strategies had been employed for Leishmania detection in bone marrow, spleen, mesenteric lymph nodes, and ear pores and skin. The infecting Leishmania species was recognized by DNA sequencing.
Outcomes: CVL prevalence (per 1,000 canine) different from 0.0-166.67, relying on the neighborhood, with a imply of 68.96 (SD 51.38). Leishmania DNA was detected in at the very least one tissue from all seropositive canine, with comparable TPR amongst tissues. Leishmania parasites had been recognized in most (54/60) seropositive canine, and the infecting parasite was recognized as Leishmania infantum in all of those.
 Membrane dynamics in Leishmania amazonensis and antileishmanial activities of β-carboline derivatives
Membrane dynamics in Leishmania amazonensis and antileishmanial activities of β-carboline derivatives

Optimized DNA-based biosensor for monitoring Leishmania infantum in human plasma samples utilizing biomacromolecular interplay: a novel platform for infectious illness prognosis

Leishmania parasite identification is essential in medical research of leishmaniasis and its prognosis. Although there are numerous medical and epidemiological approaches to figuring out Leishmania infantum, resulting from some limitations of the standard strategies, delicate and particular strategies are wanted and are in nice demand.
To attain selective and speedy detection, a delicate sign transducer with excessive floor space is important. On this work, a brand new paper sensor was fabricated utilizing silver nanoprisms electrodeposited on the GQD conductive nano-ink (Ag NPr/GQDs nano-ink). A excessive floor space and appropriate interface for anchoring biomolecules was achieved by electrodepositing gold nanoparticles (AuNPs) functionalized with cysteamine (AuNPs-CysA) on the floor of the paper sensor altered by Ag NPr/GQDs nano-ink. To organize a delicate and selective bio-device for the popularity of Leishmania in human plasma specimens, a DNA-thiol probe was stabilized on the floor of the platform.

Leishmania major PCR kit

PCR-H687-48D 50T
EUR 425.8
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania major

Leishmania major PCR kit

PCR-H687-96D 100T
EUR 521.5
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania major

Leishmania tropica PCR kit

PCR-H688-48D 50T
EUR 425.8
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania tropica

Leishmania tropica PCR kit

PCR-H688-96D 100T
EUR 521.5
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania tropica

Leishmania sp PCR kit

PCR-VH087-48D 50T
EUR 425.8
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania sp

Leishmania sp PCR kit

PCR-VH087-96D 100T
EUR 521.5
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania sp

Leishmania infantum PCR kit

PCR-VH100-48D 50T
EUR 425.8
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania infantum

Leishmania infantum PCR kit

PCR-VH100-96D 100T
EUR 521.5
  • Contact us in order to know the reactivity of the kit.
Description: An conventional PCR kit for detection of Leishmania infantum

Recombinant Leishmania Chagasi Protein

VAng-Wyb7412-1mg 1 mg
EUR 3542
Description: Leishmania Chagasi recombinant protein.

Leishmania Major Surface Protease gp63 (Leishmanolysin) Antibody

abx415772-05ml 0.5 ml
EUR 718
  • Shipped within 1 week.

Recombinant Leishmania donovani KMP11 antigen

DAG2700 1mg
EUR 1495

Rapid Leishmania Ab Test Kit

RB2104 1 box
EUR 127
Description: Please check the datasheet of Rapid Leishmania Ab Test Kit before using the test.

Leishmania tropica RT PCR kit

RTq-H680-150D 150T
EUR 701
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania tropica .

Leishmania major RT PCR kit

RTq-H687-100D 100T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania major .

Leishmania major RT PCR kit

RTq-H687-150D 150T
EUR 701
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania major .

Leishmania major RT PCR kit

RTq-H687-50D 50T
EUR 532.8
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania major .

Leishmania tropica RT PCR kit

RTq-H688-100D 100T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania tropica .

Leishmania tropica RT PCR kit

RTq-H688-50D 50T
EUR 532.8
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania tropica .

Leishmania sp RT PCR kit

RTq-VH087-100D 100T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania sp .

Leishmania sp RT PCR kit

RTq-VH087-150D 150T
EUR 701
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania sp .

Leishmania sp RT PCR kit

RTq-VH087-50D 50T
EUR 532.8
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania sp .

Leishmania infantum RT PCR kit

RTq-VH100-100D 100T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania infantum .

Leishmania infantum RT PCR kit

RTq-VH100-150D 150T
EUR 701
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania infantum .

Leishmania infantum RT PCR kit

RTq-VH100-50D 50T
EUR 532.8
  • Contact us in order to know the reactivity of the kit.
Description: A Real-Time PCR kit for detection of Leishmania infantum .

Recombinant Leishmania Amazonensis HSP83 Protein

VAng-Wyb7373-inquire inquire Ask for price
Description: Leishmania Amazonensis Heat shock protein 83, partial, recombinant protein.

Recombinant Leishmania Chagasi TOP2 Protein

VAng-Wyb7414-inquire inquire Ask for price
Description: Leishmania Chagasi DNA topoisomerase 2, partial, recombinant protein.

Recombinant Leishmania Donovani HSP70 Protein

VAng-Wyb7423-inquire inquire Ask for price
Description: Leishmania Donovani Heat shock 70 kDa protein, partial, recombinant protein.

Recombinant Leishmania chagasi K39 lipoprotein antigen

DAG2704 1mg
EUR 1495

Leishmania major One-Step PCR kit

Oneq-H687-100D 100T
EUR 747.4
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania major.

Leishmania major One-Step PCR kit

Oneq-H687-150D 150T
EUR 838.75
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania major.

Leishmania major One-Step PCR kit

Oneq-H687-50D 50T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania major.

Leishmania tropica One-Step PCR kit

Oneq-H688-100D 100T
EUR 747.4
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania tropica.

Leishmania tropica One-Step PCR kit

Oneq-H688-150D 150T
EUR 838.75
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania tropica.

Leishmania tropica One-Step PCR kit

Oneq-H688-50D 50T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania tropica.

Leishmania sp One-Step PCR kit

Oneq-VH087-100D 100T
EUR 747.4
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania sp.

Leishmania sp One-Step PCR kit

Oneq-VH087-150D 150T
EUR 838.75
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania sp.

Leishmania sp One-Step PCR kit

Oneq-VH087-50D 50T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania sp.

Leishmania infantum One-Step PCR kit

Oneq-VH100-100D 100T
EUR 747.4
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania infantum.

Leishmania infantum One-Step PCR kit

Oneq-VH100-150D 150T
EUR 838.75
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania infantum.

Leishmania infantum One-Step PCR kit

Oneq-VH100-50D 50T
EUR 628.5
  • Contact us in order to know the reactivity of the kit.
Description: Real Time PCR Kit is a screening assay for a rapid and accurate detection of Leishmania infantum.

Recombinant Leishmania chagasi K39 Protein [His]

VAng-Wyb8612-inquire inquire Ask for price
Description: Leishmania chagasi K39 protein (aa 680-955), recombinant protein from E. coli, 1.41 mg/mL.

Recombinant Leishmania donovani KMP11 antigen, Biotin-conjugated

DAG2698 1mg
EUR 1495

Recombinant Bovine p85a Protein, Untagged, Leishmania-10ug

QP12950-10ug 10ug
EUR 463

Recombinant Bovine p85a Protein, Untagged, Leishmania-20ug

QP12950-20ug 20ug
EUR 762

Recombinant Bovine p85a Protein, Untagged, Leishmania-2ug

QP12950-2ug 2ug
EUR 218

Recombinant Leishmania donovani KMP-11 Protein [His]

VAng-Wyb8611-inquire inquire Ask for price
Description: Leishmania donovani Kinetoplast Membrane Protein 11 (KMP-11), recombinant protein from E. coli, 1.59 mg/mL.

Leishmania donovani Transitional endoplasmic reticulum ATPase, putative (LDBPK_361420)

1-CSB-EP2530LOE
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 13.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Leishmania donovani Transitional endoplasmic reticulum ATPase,putative(LDBPK_361420),partial expressed in E.coli

Recombinant Leishmania chagasi K39 lipoprotein antigen, Biotin-conjugated

DAG2701 1mg
EUR 1495

Recombinant Leishmania Amazonensis gp63 Protein (aa 100-574)

VAng-Wyb7372-100gBaculovirus 100 µg (Baculovirus)
EUR 4793
Description: Leishmania Amazonensis Leishmanolysin, recombinant protein.

Recombinant Leishmania Amazonensis gp63 Protein (aa 100-574)

VAng-Wyb7372-500gBaculovirus 500 µg (Baculovirus)
EUR 6195
Description: Leishmania Amazonensis Leishmanolysin, recombinant protein.

Recombinant Leishmania Amazonensis gp63 Protein (aa 100-574)

VAng-Wyb7372-50gBaculovirus 50 µg (Baculovirus)
EUR 3335
Description: Leishmania Amazonensis Leishmanolysin, recombinant protein.

Recombinant Leishmania Amazonensis NAGT Protein (aa 1-466)

VAng-Wyb7374-1mgEcoli 1 mg (E. coli)
EUR 5508
Description: Leishmania Amazonensis UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, recombinant protein.

Recombinant Leishmania Braziliensis FEN1 Protein (aa 1-395)

VAng-Wyb7377-1mgEcoli 1 mg (E. coli)
EUR 4710
Description: Leishmania Braziliensis Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Braziliensis FEN1 Protein (aa 1-395)

VAng-Wyb7377-500gEcoli 500 µg (E. coli)
EUR 3335
Description: Leishmania Braziliensis Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Braziliensis FEN1 Protein (aa 1-395)

VAng-Wyb7377-50gEcoli 50 µg (E. coli)
EUR 2278
Description: Leishmania Braziliensis Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Braziliensis HSP70 Protein (aa 1-228)

VAng-Wyb7378-100gBaculovirus 100 µg (Baculovirus)
EUR 3954
Description: Leishmania Braziliensis Heat shock 70 kDa protein, recombinant protein.

Recombinant Leishmania Braziliensis HSP70 Protein (aa 1-228)

VAng-Wyb7378-500gBaculovirus 500 µg (Baculovirus)
EUR 5164
Description: Leishmania Braziliensis Heat shock 70 kDa protein, recombinant protein.

Recombinant Leishmania Braziliensis HSP70 Protein (aa 1-228)

VAng-Wyb7378-50gBaculovirus 50 µg (Baculovirus)
EUR 2773
Description: Leishmania Braziliensis Heat shock 70 kDa protein, recombinant protein.

Recombinant Leishmania Braziliensis ISP1 Protein (aa 1-146)

VAng-Wyb7379-1mgEcoli 1 mg (E. coli)
EUR 3129
Description: Leishmania Braziliensis Ecotin-like protein 1, recombinant protein.

Recombinant Leishmania Braziliensis ISP1 Protein (aa 1-146)

VAng-Wyb7379-500gEcoli 500 µg (E. coli)
EUR 2236
Description: Leishmania Braziliensis Ecotin-like protein 1, recombinant protein.

Recombinant Leishmania Braziliensis ISP1 Protein (aa 1-146)

VAng-Wyb7379-50gEcoli 50 µg (E. coli)
EUR 1549
Description: Leishmania Braziliensis Ecotin-like protein 1, recombinant protein.

Recombinant Leishmania Braziliensis JBP1 Protein (aa 1-813)

VAng-Wyb7380-inquire inquire Ask for price
Description: Leishmania Braziliensis Thymine dioxygenase JBP1, partial, recombinant protein.

Recombinant Leishmania Braziliensis LBRM_05_0060 Protein (aa 1-833)

VAng-Wyb7382-inquire inquire Ask for price
Description: Leishmania Braziliensis Major vault protein, partial, recombinant protein.

Recombinant Leishmania Braziliensis LBRM_14_1360 Protein (aa 1-561)

VAng-Wyb7383-inquire inquire Ask for price
Description: Leishmania Braziliensis Bifunctional NAD (P) H-hydrate repair enzyme, partial, recombinant protein.

Recombinant Leishmania Braziliensis LBRM_16_0320 Protein (aa 1-698)

VAng-Wyb7384-inquire inquire Ask for price
Description: Leishmania Braziliensis tRNA (guanine (37)-N1)-methyltransferase, partial, recombinant protein.

Recombinant Leishmania Braziliensis LBRM_20_5150 Protein (aa 1-344)

VAng-Wyb7385-1mgEcoli 1 mg (E. coli)
EUR 4380
Description: Leishmania Braziliensis 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, recombinant protein.

Recombinant Leishmania Braziliensis LBRM_20_5150 Protein (aa 1-344)

VAng-Wyb7385-500gEcoli 500 µg (E. coli)
EUR 3103
Description: Leishmania Braziliensis 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, recombinant protein.

Recombinant Leishmania Braziliensis LBRM_20_5150 Protein (aa 1-344)

VAng-Wyb7385-50gEcoli 50 µg (E. coli)
EUR 2126
Description: Leishmania Braziliensis 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM01_V2.0740 Protein (aa 1-403)

VAng-Wyb7386-1mgEcoli 1 mg (E. coli)
EUR 4765
Description: Leishmania Braziliensis Probable eukaryotic initiation factor 4A, recombinant protein.

Recombinant Leishmania Braziliensis LbrM01_V2.0740 Protein (aa 1-403)

VAng-Wyb7386-500gEcoli 500 µg (E. coli)
EUR 3363
Description: Leishmania Braziliensis Probable eukaryotic initiation factor 4A, recombinant protein.

Recombinant Leishmania Braziliensis LbrM01_V2.0740 Protein (aa 1-403)

VAng-Wyb7386-50gEcoli 50 µg (E. coli)
EUR 2291
Description: Leishmania Braziliensis Probable eukaryotic initiation factor 4A, recombinant protein.

Recombinant Leishmania Braziliensis LbrM04_V2.0780 Protein (aa 1-670)

VAng-Wyb7387-inquire inquire Ask for price
Description: Leishmania Braziliensis Pescadillo homolog, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM09_V2.1490 Protein (aa 1-187)

VAng-Wyb7388-inquire inquire Ask for price
Description: Leishmania Braziliensis Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM11_V2.0090 Protein (aa 1-743)

VAng-Wyb7389-inquire inquire Ask for price
Description: Leishmania Braziliensis Ribosome biogenesis protein BOP1 homolog, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM11_V2.0490 Protein (aa 1-406)

VAng-Wyb7390-1mgEcoli 1 mg (E. coli)
EUR 4779
Description: Leishmania Braziliensis ATPase ASNA1 homolog, recombinant protein.

Recombinant Leishmania Braziliensis LbrM11_V2.0490 Protein (aa 1-406)

VAng-Wyb7390-500gEcoli 500 µg (E. coli)
EUR 3377
Description: Leishmania Braziliensis ATPase ASNA1 homolog, recombinant protein.

Recombinant Leishmania Braziliensis LbrM11_V2.0490 Protein (aa 1-406)

VAng-Wyb7390-50gEcoli 50 µg (E. coli)
EUR 2305
Description: Leishmania Braziliensis ATPase ASNA1 homolog, recombinant protein.

Recombinant Leishmania Braziliensis LbrM13_V2.0970 Protein (aa 1-710)

VAng-Wyb7391-inquire inquire Ask for price
Description: Leishmania Braziliensis Adenylosuccinate synthetase, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM15_V2.0540 Protein (aa 1-154)

VAng-Wyb7392-1mgEcoli 1 mg (E. coli)
EUR 3184
Description: Leishmania Braziliensis Ecotin-like protein 2, recombinant protein.

Recombinant Leishmania Braziliensis LbrM15_V2.0540 Protein (aa 1-154)

VAng-Wyb7392-500gEcoli 500 µg (E. coli)
EUR 2278
Description: Leishmania Braziliensis Ecotin-like protein 2, recombinant protein.

Recombinant Leishmania Braziliensis LbrM15_V2.0540 Protein (aa 1-154)

VAng-Wyb7392-50gEcoli 50 µg (E. coli)
EUR 1563
Description: Leishmania Braziliensis Ecotin-like protein 2, recombinant protein.

Recombinant Leishmania Braziliensis LbrM15_V2.0550 Protein (aa 1-309)

VAng-Wyb7393-1mgEcoli 1 mg (E. coli)
EUR 4160
Description: Leishmania Braziliensis Ecotin-like protein 3, recombinant protein.

Recombinant Leishmania Braziliensis LbrM15_V2.0550 Protein (aa 1-309)

VAng-Wyb7393-500gEcoli 500 µg (E. coli)
EUR 2950
Description: Leishmania Braziliensis Ecotin-like protein 3, recombinant protein.

Recombinant Leishmania Braziliensis LbrM15_V2.0550 Protein (aa 1-309)

VAng-Wyb7393-50gEcoli 50 µg (E. coli)
EUR 2016
Description: Leishmania Braziliensis Ecotin-like protein 3, recombinant protein.

Recombinant Leishmania Braziliensis LbrM18_V2.0760 Protein (aa 1-470)

VAng-Wyb7394-inquire inquire Ask for price
Description: Leishmania Braziliensis Probable citrate synthase, mitochondrial, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM19_V2.0670 Protein (aa 1-379)

VAng-Wyb7395-inquire inquire Ask for price
Description: Leishmania Braziliensis Lipoyl synthase, mitochondrial, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM20_V2.0500 Protein (aa 1-831)

VAng-Wyb7396-inquire inquire Ask for price
Description: Leishmania Braziliensis Translation factor GUF1 homolog, mitochondrial, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM25_V2.1130 Protein (aa 1-236)

VAng-Wyb7397-1mgEcoli 1 mg (E. coli)
EUR 3707
Description: Leishmania Braziliensis Alpha-tubulin N-acetyltransferase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM25_V2.1130 Protein (aa 1-236)

VAng-Wyb7397-500gEcoli 500 µg (E. coli)
EUR 2649
Description: Leishmania Braziliensis Alpha-tubulin N-acetyltransferase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM25_V2.1130 Protein (aa 1-236)

VAng-Wyb7397-50gEcoli 50 µg (E. coli)
EUR 1796
Description: Leishmania Braziliensis Alpha-tubulin N-acetyltransferase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM28_V2.2010 Protein (aa 1-225)

VAng-Wyb7398-1mgEcoli 1 mg (E. coli)
EUR 3638
Description: Leishmania Braziliensis Probable methylthioribulose-1-phosphate dehydratase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM28_V2.2010 Protein (aa 1-225)

VAng-Wyb7398-500gEcoli 500 µg (E. coli)
EUR 2594
Description: Leishmania Braziliensis Probable methylthioribulose-1-phosphate dehydratase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM28_V2.2010 Protein (aa 1-225)

VAng-Wyb7398-50gEcoli 50 µg (E. coli)
EUR 1769
Description: Leishmania Braziliensis Probable methylthioribulose-1-phosphate dehydratase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM29_V2.0730 Protein (aa 1-276)

VAng-Wyb7399-inquire inquire Ask for price
Description: Leishmania Braziliensis Elongation factor Ts, mitochondrial, partial, recombinant protein.

Recombinant Leishmania Braziliensis LbrM32_V2.0440 Protein (aa 1-891)

VAng-Wyb7400-1mgEcoli 1 mg (E. coli)
EUR 8189
Description: Leishmania Braziliensis Protein SEY1 homolog, recombinant protein.

Recombinant Leishmania Braziliensis LbrM34_V2.0430 Protein (aa 2-264)

VAng-Wyb7401-1mgEcoli 1 mg (E. coli)
EUR 3872
Description: Leishmania Braziliensis 40S ribosomal protein S3a, recombinant protein.

Recombinant Leishmania Braziliensis LbrM34_V2.0430 Protein (aa 2-264)

VAng-Wyb7401-500gEcoli 500 µg (E. coli)
EUR 2759
Description: Leishmania Braziliensis 40S ribosomal protein S3a, recombinant protein.

Recombinant Leishmania Braziliensis LbrM34_V2.0430 Protein (aa 2-264)

VAng-Wyb7401-50gEcoli 50 µg (E. coli)
EUR 1879
Description: Leishmania Braziliensis 40S ribosomal protein S3a, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.5180 Protein (aa 1-374)

VAng-Wyb7402-1mgEcoli 1 mg (E. coli)
EUR 4573
Description: Leishmania Braziliensis Methylthioribose-1-phosphate isomerase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.5180 Protein (aa 1-374)

VAng-Wyb7402-500gEcoli 500 µg (E. coli)
EUR 3239
Description: Leishmania Braziliensis Methylthioribose-1-phosphate isomerase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.5180 Protein (aa 1-374)

VAng-Wyb7402-50gEcoli 50 µg (E. coli)
EUR 2209
Description: Leishmania Braziliensis Methylthioribose-1-phosphate isomerase, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.5370 Protein (aa 1-246)

VAng-Wyb7403-1mgEcoli 1 mg (E. coli)
EUR 3762
Description: Leishmania Braziliensis 40S ribosomal protein SA, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.5370 Protein (aa 1-246)

VAng-Wyb7403-500gEcoli 500 µg (E. coli)
EUR 2690
Description: Leishmania Braziliensis 40S ribosomal protein SA, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.5370 Protein (aa 1-246)

VAng-Wyb7403-50gEcoli 50 µg (E. coli)
EUR 1824
Description: Leishmania Braziliensis 40S ribosomal protein SA, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.7020 Protein (aa 1-398)

VAng-Wyb7404-1mgEcoli 1 mg (E. coli)
EUR 4724
Description: Leishmania Braziliensis Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.7020 Protein (aa 1-398)

VAng-Wyb7404-500gEcoli 500 µg (E. coli)
EUR 3335
Description: Leishmania Braziliensis Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, recombinant protein.

Recombinant Leishmania Braziliensis LbrM35_V2.7020 Protein (aa 1-398)

VAng-Wyb7404-50gEcoli 50 µg (E. coli)
EUR 2278
Description: Leishmania Braziliensis Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, recombinant protein.

Recombinant Leishmania Braziliensis LIP2 Protein (aa 1-105)

VAng-Wyb7405-1mgEcoli 1 mg (E. coli)
EUR 2869
Description: Leishmania Braziliensis 60S acidic ribosomal protein P2, recombinant protein.

Recombinant Leishmania Braziliensis LIP2 Protein (aa 1-105)

VAng-Wyb7405-500gEcoli 500 µg (E. coli)
EUR 2058
Description: Leishmania Braziliensis 60S acidic ribosomal protein P2, recombinant protein.

Recombinant Leishmania Braziliensis LIP2 Protein (aa 1-105)

VAng-Wyb7405-50gEcoli 50 µg (E. coli)
EUR 1425
Description: Leishmania Braziliensis 60S acidic ribosomal protein P2, recombinant protein.

Recombinant Leishmania Chagasi gp63 Protein (aa 98-574)

VAng-Wyb7406-100gBaculovirus 100 µg (Baculovirus)
EUR 4793
Description: Leishmania Chagasi Leishmanolysin, recombinant protein.

Recombinant Leishmania Chagasi gp63 Protein (aa 98-574)

VAng-Wyb7406-500gBaculovirus 500 µg (Baculovirus)
EUR 6209
Description: Leishmania Chagasi Leishmanolysin, recombinant protein.

Recombinant Leishmania Chagasi gp63 Protein (aa 98-574)

VAng-Wyb7406-50gBaculovirus 50 µg (Baculovirus)
EUR 3335
Description: Leishmania Chagasi Leishmanolysin, recombinant protein.

Recombinant Leishmania Chagasi KIN Protein (aa 1-955)

VAng-Wyb7409-inquire inquire Ask for price
Description: Leishmania Chagasi Kinesin-like protein K39, partial, recombinant protein.

Recombinant Leishmania Chagasi LCP0 Protein (aa 1-322)

VAng-Wyb7410-100gBaculovirus 100 µg (Baculovirus)
EUR 4270
Description: Leishmania Chagasi 60S acidic ribosomal protein P0, recombinant protein.

Recombinant Leishmania Chagasi LCP0 Protein (aa 1-322)

VAng-Wyb7410-500gBaculovirus 500 µg (Baculovirus)
EUR 5563
Description: Leishmania Chagasi 60S acidic ribosomal protein P0, recombinant protein.
Hybridization of DNA was evaluated by chronoamperometry (ChA). The engineered DNA-based paper biosensor confirmed excessive sensitivity and selectivity for the identification of Leishmania genomic DNA. Below optimum circumstances, a linear vary was obtained utilizing photographic paper from 1 μM to 1 zM and an ivory sheet from 1 nM to 1 zM. The decrease limits of quantitation (LLOQ) on the photographic paper and ivory sheet had been 1 zM. As well as, the designed DNA-based biosensor revealed well-defined efficiency within the recognition of mismatched sequences (single base, two base and three base mismatches) and selectivity.

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